UC Davis Veterinary Clinical Trials

VACCS: Vaccination Against Canine Cancer Study

Help us prevent cancer in dogs with a new vaccine!

Cancer is the leading cause of death in dogs, accounting for approximately 30% of all deaths. Certain breeds have much higher likelihoods of cancer than others. “Tumor antigens” are proteins that can be recognized by the immune system as foreign and result in the attack of tumors by the immune system. Researchers have identified a series of new tumor antigens that appear to be produced in multiple types of cancer very early in tumor development and are produced in cancers from many species (humans, dogs and mice). Vaccination of mice with these antigens can delay or prevent multiple types of cancer without side effects. The purpose of this study is to determine whether vaccination with these novel tumor antigens is capable of reducing the likelihood of cancer in dogs.

Preventative vaccine study

Assessing and managing megaesophagus in dogs

Help us find better ways of treating dogs with megaesophagus!

Megaesophagus literally means large or giant esophagus and refers to a syndrome in which the muscles of the esophagus lose their tone and are no longer able to propel food and water from the mouth into the stomach. This disease is common in large-breed dogs in particular and can occur at any age. While some other diseases can cause megaesophagus, in over 50% of dogs no underlying or treatable cause is identified (known as idiopathic-acquired megaesophagus). As such, no targeted therapy can be implemented. Few advancements have been made in recommendations for disease management with current suggestions documented to be inadequate. We are assessing esophageal and lower esophageal sphincter (LES) function to optimize management of megaesophagus (ME) using novel medical therapies.

Using stem cells to help cats with gingivostomatitis after having received a full dental extraction

Help us treat cats with gingivostomatitis!

Feline chronic gingivostomatitis (FCGS) is a painful disease in cats that needs medical or surgical treatments. A stem cell therapy where stem cells are taken from fat tissue is a new potential therapy for chronic inflammatory diseases. This cell therapy MAY help to correct abnormalities that may be involved with stomatitis in cats. Moreover, stem cells may help in regenerating damaged tissues. In this study, we will evaluate the effectiveness of using stem cells to treat cats with gingivostomatitis that have had full or near-full mouth extractions.

Stem Cell Study